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. 2017 Jul 6;8(48):83354–83369. doi: 10.18632/oncotarget.19042

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Copyright: © 2017 Jacamo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A., Enrichment plots showing association of up- and down-regulated genes in this database with mitochondria functions. B., DAVID Functional Annotation Clustering report displaying grouped annotations with the higher enrichment scores for this dataset. The p-values associated with each annotation terms inside each clusters are exactly the same meaning/values as p-values (Fisher Exact/EASE Score) shown in the regular chart report for the same terms. FDR: False Discovery Rate. C., IPA Canonical Pathways analysis displaying the most significant pathways associated with down-regulated genes induced by MLL/ENL+FLT3-ITD Trp53^-/- leukemia in BM-MSC. The Stacked Bar Chart displays the down-regulated genes molecules in each Canonical Pathway with regards to their z-score. The color blue reflects a negative direction of change for the function. Z-scores ≤ -2 indicate that the function has a statistically significant decrease.