Table 2. Similarities and differences between DEG in BM-MSC from mice engrafted with either MLL/ENL+FLT3-ITD Trp53^-/- or MLL/ENL+FLT3-ITD Trp53 wt.

MLL/ENL+FLT3-ITD Trp53-/-	MLL/ENL+FLT3-ITD Trp53 wt
Similarities: Activation of β-Catenin Genes up-regulated in HSC	Activation of β-Catenin Genes up-regulated in HSC
Differences: Hypoxia Activation of MYC Mitochondrial functions, ribosome assembly, RNA translation and RNA metabolic functions Activation of C-Rel and NRF2 Inhibition of PI3K, PLC, TGF-β	Activation of AHR Activation of TATA Collagen formation Activation of Polo-like kinase, Integrins, mTOR and NGF Inhibition of IL-8, IL-6, cytokines production, NFAT-mediated regulation of immune response, TLR-mediated signaling and Rho family of GTPases

Summary of changes in GEP observed in BM-MSC under the two experimental conditions. GSEA and IPA were used as analysis tools to determine similarities and differences presented.