Figure 3. Detection of actionable mutations.

Variants with therapeutic implications were detected in both tumor tissue and cfDNA. Patients are subdivided into those with tumor tissue and cfDNA data (left block), cfDNA only (middle block), and tumor tissue and ctcDNA (right block). Variants found in tumor tissue NGS analysis are indicated by a red square, variants found in cfDNA-based NGS analysis are indicated by a blue square, and the sole concordant variant is indicated by a half-red/half-blue square. Patients for whom tumor quantity was insufficient for tissue-based NGS are shaded in gray.