Figure 3. Overexpression of p300 reversed SH-I-14-mediated deacetylation of STAT3.

HEK293T cells were transfected with STAT3 expression vector in the absence or presence of p300 expression vector. The cells were further treated with increasing amount of SH-I-14 for 24 hr and western blot analysis was performed with indicated antibodies. β-actin was used as a loading control.