. 2017 Jun 28;8(48):83570–83584. doi: 10.18632/oncotarget.18784

Table 2. Metabolites significantly associated with treatment T+E.

ID	Name	W0 vs. W1			W0 vs. W4			W0 vs. W7			W0 vs. W9			Variation
ID	Name	p-value^a	q-value BH^b	Fold Change	p-value^a	q-value BH^b	Fold Change	p-value^a	q-value BH^b	Fold Change	p-value^a	q-value BH^b	Fold Change	Variation
1	Acetate	0.003	0.038	0.73	0.003	0.019	0.71	0.001	0.006	0.66				↓
2	Acetoacetate				0.009	0.042	0.84	0.001	0.009	0.79	0.001	0.023	0.83	↓
3	Acetone	0.0006	0.025	1.27	0.0001	0.002	1.44	0.0001	0.002	1.39				↑
4	Alanine	0.001	0.032	0.83	0.001	0.010	0.80	0.001	0.006	0.81				↓
5	Albumin Lysyl	0.002	0.038	0.83	0.00004	0.002	0.77	0.0006	0.006	0.81				↓
6	Betaine	0.004	0.038	0.82	0.0003	0.005	0.76	0.002	0.012	0.77				↓
7	Choline				0.007	0.040	0.88	0.003	0.016	0.86				↓
8	Citrate				0.002	0.015	0.80							↓
9	Creatine	0.001	0.032	0.83	0.00001	0.001	0.78	0.000001	0.00001	0.76				↓
10	Creatinine	0.00002	0.002	0.86	0.000002	0.0003	0.78	0.000001	0.00001	0.76				↓
11	Fatty acids	0.0006	0.025	1.27	0.010	0.046	1.23	0.001	0.009	1.32	0.003	0.041	1.12	↑
12	Fatty acids (mainly LDL)				0.002	0.015	1.32	0.001	0.006	1.37				↑
13	Fatty acids (mainly VLDL)				0.002	0.015	1.35	0.002	0.012	1.35				↑
14	Glucose				0.002	0.018	0.86	0.0002	0.004	0.82	0.0003	0.013	0.84	↓
15	Glycerol backbone of PGLYs & TAGs				0.003	0.019	1.15	0.001	0.006	1.21	0.0001	0.013	1.20	↑
16	Glycerophosphocholine				0.007	0.040	0.82	0.001	0.006	0.79				↓
17	Histidine	0.004	0.040	0.85	0.0003	0.005	0.82	0.0004	0.006	0.78				↓
18	Isoleucine							0.008	0.035	0.85				↓
19	Lysine	0.001	0.032	0.85	0.001	0.008	0.81	0.0001	0.002	0.79				↓
20	Mannose							0.009	0.036	1.30				↑
21	Methanol				0.002	0.016	0.80	0.001	0.008	0.78				↓
22	Myo-inositol				0.0001	0.003	0.78	0.0001	0.002	0.75				↓
23	NAC 1							0.002	0.011	1.10	0.0003	0.013	1.15	↑
24	Phenylalanine	0.0003	0.019	0.64	0.0003	0.005	0.58	0.001	0.008	0.63	0.002	0.037	0.59	↓
25	Proline							0.001	0.008	0.78				↓
26	Tyrosine	0.002	0.038	0.83	0.00001	0.001	0.74	3 × 10 ^-8	0.00001	0.67	0.0002	0.012	0.78	↓
27	Valine	0.004	0.038	0.81	0.010	0.046	0.89	0.00002	0.0008	0.70	0.004	0.044	0.86	↓

^a p-value without multiple testing correction.

^b q-value BH: p-value after Benjamini-Hochberg false discovery rate multiple testing correction. Variation: ↑ corresponds to higher concentration in W1, W4, W7 or W9 serum metabolic profiles than at baseline; ↓ to lower concentration in W1, W4, W7 or W9 serum metabolic profiles than at baseline.