Table 4. Comparison of effects of different variables on acute and chronic GVHD occurrence after transplantation.
| Variable | aGVHD (grades III-IV) | cGVHD (extensive) | ||
|---|---|---|---|---|
| Event/total | P value | Event/total | P value | |
| Patient age at transplant | 0.944 | 0.247 | ||
| <15 yr | 5/49 | 2/48 | ||
| ≥15 yr | 3/28 | 3/27 | ||
| Diagnosis-to-transplant interval | 0.969 | 0.291 | ||
| ≤6 months | 4/38 | 1/38 | ||
| >6 months | 4/39 | 3/37 | ||
| Patient sex | 0.146 | 0.174 | ||
| Female | 2/38 | 1/37 | ||
| Male | 6/39 | 4/38 | ||
| IST prior to referral for HSCT | 0.142 | 0.738 | ||
| ATG included | 0/15 | 1/14 | ||
| ATG excluded | 8/62 | 3/61 | ||
| Transfusion RBC before HSCT | 0.126 | 0.034 | ||
| ≥25U | 5/29 | 4/27 | ||
| <25U | 3/48 | 1/48 | ||
| Conditioning regimen | 0.633 | 0.239 | ||
| A(Flu+Cy+ATG+Bu) | 5/42 | 4/41 | ||
| B(Flu+Cy+ATG) | 3/35 | 1/34 | ||
| Time to neutrophil engraftment | 0.907 | 0.174 | ||
| ≥12 days | 4/40 | 4/38 | ||
| <12 days | 4/37 | 1/37 | ||
| Time to platelet engraftment | 0.746 | 0.456 | ||
| ≥14 days | 5/44 | 2/42 | ||
| <14 days | 3/33 | 3/33 | ||
| Donor age | 0.438 | 0.003 | ||
| <45yr | 6/65 | 2/64 | ||
| ≥45 yr | 2/12 | 3/11 | ||
| D-R sex match | 0.992 | 0.949 | ||
| Match | 5/48 | 3/46 | ||
| Mismatch | 3/29 | 2/29 | ||
| D-R major blood group match | 0.689 | 0.456 | ||
| Match | 5/43 | 2/42 | ||
| Mismatch | 3/34 | 3/33 | ||
| D-R HLA mismatched | 0.014 | 0.316 | ||
| 2-4 HLA loci | 0/31 | 1/31 | ||
| 5 HLA loci | 8/46 | 4/44 | ||
D-R, donor-recipient.