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. 2017 Jul 31;8(48):83831–83844. doi: 10.18632/oncotarget.19747

Figure 2. MCU expression promotes the Warburg effect in breast cancer cells.

Figure 2

(A) Glucose (Glu) uptake, ATP levels, LDH levels, and lactate production in MDA-MB-231 and MCF7 cells. (B) Glucose uptake, ATP levels, LDH levels, and lactate production in MDA-MB-231 cells transfected with a lentivirus expressing sh-MCU or sh-NC. (C) Glucose uptake, ATP levels, LDH levels, and lactate production in MDA-MB-231 cells treated with Ru360 (an MCU inhibitor) or spermine (an MCU agonist). (D) Glucose uptake, ATP levels, LDH levels, and lactate production in MCF7 cells transfected with lenti-MCU or lenti-NC. The error bars in all the bar graphs represent SD. Statistical significance was determined via one-way analysis of variance followed by pairwise t-tests.*P<0.05; **P< 0.01.