Table 3. Positive rates of p16/Ki-67, p16/mcm2 dual staining in different HPV infection status.

HPV status	p16/Ki-67			p16/mcm2
	N (%)	χ2	P	N (%)	χ2	P
HR-HPV negative (n=461)	41 (8.9)	ref	-	31 (6.7)	ref	-
Other 12 HR-HPV positive (n=279)	94 (33.7)	71.7	<0.01	157 (56.3)	225.2	<0.01
HPV16/18 positive (n=50)	25 (50.0)	67.8	<0.01	35 (70.0)	160.6	<0.01

Other 12 HR-HPV positive: positive for any of the 12 HPV types (HPV 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68), and negative for HPV16/18.