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. 2017 Aug 10;8(48):83925–83939. doi: 10.18632/oncotarget.20202

Figure 2. CYC065 in combination with eribulin decreased colony size of MDA-MB-231 cells in 3D Matrigel matrices over time when compared to individual treatments.

Figure 2

(A) Representative optical microscopy images of MDA-MB-231 colonies cultured on top of 3D Matrigel at day 2 and day 4 post-treatment for control, CYC065, eribulin, and combination treatment (CYC065+eribulin). (B) Quantification of colony size for all conditions in 3D Matrigel matrices. (N = 4 hydrogels per group; n ≥ 65 colonies per group). * indicates groups that are statistically significant from control and CYC065 + eribulin but not each other. ** indicates groups that are statistically significant from all other groups (p < 0.05).