Figure 1. LiCl alleviated inflammatory responses and suppressed bone loss stimulated by Ti particles in a calvarial osteolysis model.

(A) Three-dimensional reconstruction images of mice calvariae were obtained from each group (Scar bar = 5 mm). (B) BMD (mg/cc), (C) BV/TV (%), (D) pore number, and (E) area of porosity (%) were determined by high-resolution μCT and relevant analysis software. (F) Calvarial section images stained for H&E and TRAP in each group were observed using a high-quality light microscope (Scar bar = 100 μm). (G) Eroded surface (mm²), (H) TRAP-positive cell number (purple, indicated by the arrows), and (I) the percentages of osteoclasts per bone surface (OCs/BS, %) were quantified (^*P<0.05 and ^**P<0.01).