Table 4. Adverse event.

AE	AI+Met				AI
	Grade 1	Grade 2	Grade 3	Grade 4	Grade 1	Grade 2	Grade 3	Grade 4
Anemia	0	0	1(3.33%)	0	0	0	0	0
Neutropenia	0	0	0	0	1(3.33%)	0	0	0
Thrombocytopenia	0	0	0	1(3.33%)	0	0	0	0
Fever	1(3.33%)	0	0	0	1(3.33%)	0	0	0
Diarrhea	1(3.33%)	1(3.33%)	0	0	0	0	0	0
Anorexia	1(3.33%)	0	0	0	1(3.33%)	0	0	0
Fatigue	1(3.33%)	0	0	0	2(6.67%)	0	0	0
Nausea and vomiting	2(6.67%)	0	0	0	0	0	0	0
Abdominal distension	1(3.33%)	0	0	0	0	0	0	0
Constipation	1(3.33%)	0	0	0	0	0	0	0
Arthralgia	5(16.7%)	0	0	0	3(10.0%)	0	0	0
Alopecia	0	0	0	0	0	0	0	0
Rash	0	0	0	0	1(3.33%)	0	0	0
Edema	0	0	0	0	1(3.33%)	0	0	0
Liver enzyme escalation	2(6.67%)	0	0	0	2(6.67%)	0	0	0
Myalgia	0	0	0	0	1(3.33%)	0	0	0
Headache	3(10.0%)	0	0	0	0	0	0	0
Skin Pruritus	0	0	0	0	1(3.33%)	0	0	0
Cough	0	1(3.33%)	0	0	0	0	0	0
Insomnia	1(3.33%)	0	0	0	0	0	0	0
Hand-foot syndrome	0	1(3.33%)	0	0	0	0	0	0