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. 2017 Sep 28;8(48):84434–84448. doi: 10.18632/oncotarget.21375

Figure 1. The expression of identified genes by integrative transcriptome and methylome analyses is silenced by DNA methylation in ESCC.

Figure 1

(A) Transcript levels of PITX1, PRSS27, CST6, and HOPX were determined by qRT-PCR in duplicate for 32 ESCC samples. Expression levels are reported relative to the mean levels of normal tissues. (B) The mRNA induction of PITX1, PRSS27, CST6, and HOPX in ESCC cell lines after treatment with 1 μM or 5 μM of 5-aza-dC. Data are reported as the fold increase in induction relative to that in untreated cells and shown as mean ± SD of assays performed in duplicate. *P<0.05, **P<0.01.