Table 2. Impact of TSP1 on cancer cell behaviors.
| Author | Cancer | TSP1 expression | Impact of TSP1 on cancer cell behaviors | Prognosis |
|---|---|---|---|---|
| Chandrasekaran et al.53 Gomes et al.54 John et al.55 |
Breast cancer | - | Pro-adhesive activity | - |
| Albo et al.60 | Breast cancer | - | Promoted invasion Decreased adhesion |
- |
| Ndishabandi et al.72 | Breast cancer | - | Promoted tumor growth and decreasedmetastasis | - |
| Hyder et al.77 | Breast cancer | - | Promoted proliferation (low concentration) Decreased proliferation (high concentration) |
- |
| Horiguchi et al.65 | Invasive ductal carcinoma of the breast | Increased (IHC) |
Promoted lymph node metastasis | - |
| Sipes et al.56 | Melanoma | - | Pro-adhesive activity | - |
| Borsotti et al.64 | Melanoma | Increased (microarray analysis) |
Promoted invasion and metastasis | - |
| Jayachandran et al.66 | Melanoma | - | Promoted invasion, chemoresistance andmesenchymal phenotypes | - |
| Guo et al.57 | SCLC | - | Pro-adhesive activity | - |
| Decker et al.58 | Osteosarcoma | - | Pro-adhesive activity | - |
| Streit et al.59 | Cutaneous squamous cell carcinoma | - | Pro-adhesive activity No effect on proliferation and apoptosis |
- |
| Pal et al.61 | Oral squamous cell carcinoma | Increased (IHC and cDNA microarray ) |
Promoted migration and invasion | - |
| Motegi et al.63 | Oral tumor | - | Promoted migration | - |
| Seliger et al.62 | Glioma | - | Promoted migration | - |
| Firlej et al.67 | Prostate cancer | - | Promoted migration and invasion | - |
| Goel et al.78 | Prostate cancer | - | No effect on proliferation and apoptosis | - |
| Nucera et al.68 | Papillary thyroid carcino-ma | - | Promoted invasion and metastasis | - |
| Soula-Rothhut et al.69 | Thyroid cancer | - | Promoted migration and invasion | - |
| Zhou et al.70 | Medulloblasto-ma | - | Promoted migration and invasion | - |
| Huang et al.71 | Gastric cancer | Increased (IHC) |
Promoted migration and invasion | - |
| Bienes-Martinez et al.73 | Clear cell renal Carcinoma |
- | Decreased migration and invasion | - |
| Zubac et al.79 | Clear cell renal Carcinoma |
Decreased (IHC) |
Decreased proliferation | Survival |
| Tzeng et al.74 | Esophageal squamous cell carcinoma | Decreased (IHC) |
Decreased migration and metastasis | Progression-free survival |
| Gutierrez et al.75 | Intestinal adenoma | - | Decreased proliferation and promoted apoptosis | - |
| Lopez-Dee et al.76 | Colorectal cancer | - | Decreased proliferation | - |
IHC: The expression of TSP1 was examined by immunohistochemical analysis in cancer tissues.