Fig 5. Electroretinogram (ERG) responses are diminished in Bbs8^-/-, Bbs4^-/-, and Bbs1^M390R/M390R mice.

Scotopic ERG responses of P21 mutant mice are significantly reduced compared to their control wild type or heterozygous littermates. Signals of a- and b- waves (a- wave, top panel, b- wave, bottom panel), plotted against Log₁₀ of luminance, are attenuated under dim (0.1564 cd·s/m²), intermediate (1.252 cd·s/m²) and bright (40 cd·s/m²) luminance conditions. Representative traces show the ERG response of a mutant mouse compared to its control littermate at the intermediate luminosity. Bar graphs show a- and b- wave signals (a- wave, top panel, b- wave, bottom panel) at the intermediate luminosity (1.252 cd·s/m²) condition.