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. 2017 Oct 19;13(10):e1007057. doi: 10.1371/journal.pgen.1007057

Fig 6. Deletion of Bbs8 in adult and infantile mice causes retinal degeneration.

Fig 6

(A, F) BBS8 protein levels two weeks after the end of tamoxifen injections (2 weeks post tamoxifen, 2WP-TMX) in adult (A) and infantile (F) cohorts. (B, G) Retinal histology shows progressive retinal degeneration in tamoxifen-treated mice (adult, B; infantile, G). (C, H) STX3 localization (green) and a- and b-wave amplitudes in electroretinograms (ERG) of Cre- and Cre+ mice at 2WP-TMX (adult, C; infantile, H). The outer segment is labeled with an antibody against rhodopsin (RHO, red). (D, I) STX3 localization and ERG amplitudes at one month after the end of tamoxifen injections (1MP-TMX) (adult, D; infantile, I). (E, J) STX3 localization and ERG amplitudes at 7MP-TMX (adult, E; infantile, J). All scale bars represent 20 μm. OS: outer segment. P values for two-tailed Welsh’s test are shown: * denotes p<0.05, ** denotes p < 0.01, *** denotes p < 0.005, **** denotes p < 0.001, ***** denotes p < 0.0005.