Fig 13. Outer segment morphology in rescued (Bbs8^gt/gt; Flp⁺, tamoxifen treated) mice at P14 and P17.

Outer segment morphology was examined by transmission electron microscopy at P14 (2 days after the 2^nd tamoxifen injection) and P17 (2 days after the 3rd tamoxifen injection). At P14, the majority of outer segments are still elongated and vertically oriented in rescued (Bbs8^gt/gt; Flp⁺) mice similar to Bbs8^gt/gt; Flp^- mice; arrowheads. At P17, numerous outer segments with disorganized and vertically oriented discs at the distal end but well-stacked discs at the proximal end can be observed in Bbs8^gt/gt; Flp⁺ mice; arrowheads.