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Properties of the Mammalian CRACM Proteins
| CRACM1 | CRACM2 | CRACM3 | |
|---|---|---|---|
| Store-operated | Yes | Yes | Yes |
| Activation time (t1/2) | 35 ± 7 s | 21 ± 3 s | 63 ± 7 s |
| Ca2+-dependent inactivation (fast) | Moderate | Moderate | Strong |
| Ca2+-dependent inactivation (slow) | Strong | None | None |
| Ca2+-dependent reactivation | Yes | No | No |
| Selectivity | Ca2+ >> Na+, Ba2+ | Ca2+ >> Na+, Ba2+ | Ca2+ >> Na+, Ba2+ |
| Monovalent permeation in DVF solutions | Moderate | Moderate | Strong |
| 2-APB effect at 50 μM | Block | Reduction | Potentiation |
