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. 2017 Oct 27;8:1416. doi: 10.3389/fimmu.2017.01416

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Copyright © 2017 Dedeoglu, Litjens, de Weerd, Dor, Klepper, Reijerkerk, Baan and Betjes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RTL, RTE frequency and TREC content in the lymph node between rejection and no rejection groups. The RTL of (A) CD4⁺ T cells and (B) CD8⁺ (T cells) within the lymph nodes between the no rejection and rejection groups are shown. Frequencies of (C) CD4⁺ and (D) CD8⁺ RTEs (CD31⁺ naïve T cells) within the lymph nodes between the no rejection and rejection group are shown. (E) The TREC content (1/ΔCT) within the lymph nodes between the no rejection and rejection group is shown. Data are shown as individual points and medians. Significant differences were calculated and shown (*p < 0.05, **p ≤ 0.01, ***p ≤ 0.001). RTEs, recent thymic emigrants; RTL, relative telomere length; TREC, T-cell receptor excision circle.