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. 2017 Oct 31;8:1212. doi: 10.1038/s41467-017-01422-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Inter-individual variability of organelle proteome alternations induced by T21. a High correlation of organelle proteome regulation trends between twins and unrelated samples. b The correlation between log₂ T1DS/T2N ratios for each organelle and the inter-individual variability of T21/normal FC using unrelated samples. ER, endoplasmic reticulum. c The distribution of T21/normal ratios of mitochondrial proteins and other proteins in the proteome, for twin samples and unrelated individuals. d The distribution of T21/normal ratios of cytosolic ribosome proteins (Cyto_Ribo), mitochondrial ribosome proteins (Mito_Ribo), and other proteins in the proteome, for twin samples and unrelated individuals