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. 2017 Oct 31;7:14407. doi: 10.1038/s41598-017-14986-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of SNPs identified in T. cruzi clones selected for benznidazole-resistance. (a) Venn diagram illustrating the distribution of 26,495 distinct SNPs identified by genome sequencing of three drug-resistant clones. (b) The total number of SNPs in coding and non-coding genomic regions are shown in purple and yellow. The smaller circle (right) illustrates SNP distribution within coding regions: missense (green), silent (grey) and nonsense/nonstop (orange). (c) Classification of missense SNPs as transitions (purine ↔ purine; blue) or transversions (purine ↔ pyrimidine; pink). (d) Maximum-likelihood phylogenetic tree based on nucleotide alignment (FastTree program), showing relationship between parental and drug-resistant T. cruzi clones. Scale bar represents the number of substitutions per site.