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. 2017 Oct 31;7:14407. doi: 10.1038/s41598-017-14986-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Multi-drug resistance following benznidazole-selection. (a–e) EC₅₀ values were obtained (Methods) for the parental Y strain (P) and drug-resistant clones 1–3 (epimastigotes) against benznidazole, nifurtimox, fexinidazole, fexinidazole sulfone and posaconazole. The fold-resistance is indicated above each bar. (f) Benznidazole and posaconazole susceptibility of parental parasites and two genetically modified clones in which one copy of the TcNTR-1 gene had been deleted. Each experiment was performed 3 times in triplicate.