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. 2017 Oct 31;7:14393. doi: 10.1038/s41598-017-14807-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Different degrees of enrichment of expression between circRNAs and their host genes in 38 single cells. (A) Correlation analysis for circRNA-Freq and SNP-Freq in 38 single-cell samples; (B) Correlation of circRNA-gene ratio and host gene FPKM; (C) A negative correlation between expression of circRNAs and host genes; (D) The expressed enrichment of circRNA host genes. (E) The random distribution of circRNA host genes within the sorted list who contained all the genes with SNPs. (F) The enrichment of circRNA host genes sorted by counts of miRNA. The horizontal axes in (E), (D) and (F) represent gene list with expressed gene, SNPs and miRNAs, respectively. And they were ordered by expression level, counts of SNPs and counts of miRNA sites from high to low, respectively. Vertical bars represent the location of circRNA host genes within the sorted lists. The ES values were the maximum deviation from zero encountered in the random walk. The upper curves represent the dynamic ES value.