Table 1.

Representative circRNA host genes in the pathway analysis.

Pathway	circRNA host genes
Lysine degradation**	HADH, ASH1L, SETD2, WHSC1, NSD1, WHSC1L1, EHMT1
Ubiquitin mediated proteolysis**	HUWE1, SMURF1, TRIM37, UBE4B, UBE2G1, CUL5, BIRC6, UBE2I, UBR5, MID1
ErbB signaling pathway**	PIK3CB, PTK2, CRKL, PIK3R3, BRAF, ABL2, MTOR
Protein processing in endoplasmic reticulum**	PDIA6, SEC31B, UBE4B, UBQLN1, UBE2G1, SEC62, NPLOC4, AMFR, MAN1A2
Insulin signaling pathway**	PIK3CB, CRKL, PIK3R3, BRAF, ACACB, ACACA, PRKAG2, MTOR
RNA transport*	NUP214, RANGAP1, KPNB1, CASC3, UBE2I, EIF4G3, NUP205, NDC1
Amoebiasis*	PIK3CB, PTK2, PLCB1, PIK3R3, ADCY1, RAB7A
Selenocompound metabolism*	MTR, PAPSS1, MARS
Bacterial invasion of epithelial cells*	PIK3CB, PTK2, CRKL, PIK3R3, CD2AP
AMPK signaling pathway*	PIK3CB, PIK3R3, ACACA, PRKAG2, PPARG, MTOR

Note: Genes harboring circRNAs were observed to be involved in ten pathways by p-value cutoff at 0.05. (*p < 0.05, **p < 0.01).