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. 2017 Oct 31;8:1220. doi: 10.1038/s41467-017-01332-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Rod-RBC synapses exist in different configurations. a Maximum intensity projection of a confocal image stack of the outer plexiform layer of a retina, in which rods were electroporated with Nrl-DsRed (gray) and in which RBC postsynaptic sites were stained for Gpr179 (red). Scale bar represents 5 μm. The top panel shows an overview, whereas the bottom panels present higher magnification views of individual rod spherules. b Histogram of the number of Gpr179 clusters per rod observed in our data (n = 555 rods, n = 12 mice). Scale bar represents 0.5 μm. c Analogous to a, but showing AAV-mediated (Grm6 _S -tdTomato) labeling of an individual RBC in gray. For visual clarity, the RBC and rod synapses were digitally isolated in Amira. d Population data (mean ± SEM) showing the distribution of postsynaptic densities assembled by each RBC per rod spherule (n = 29 RBCs, n = 8 mice)