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. 2017 Oct 31;7:14459. doi: 10.1038/s41598-017-14852-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DLS measurements of functionalized MGs. Hydrodynamic radius (R_h) of the native (pNIPAm-co-AAc) MGs (red squares) and functionalized (pNIPAm-APBA) MGs before (black triangles) and after glucose binding (blue circles) as a function of temperature (a), R_h variations (R_h - R₀) of the (pNIPAm-APBA) MGs as function of time during glucose binding at 16 mM, for temperatures of 14 (blue) and 20 °C (red), black triangles curve represents R_h variations for not functionalized MGs (negative control) (b). R_h variations as a function of time for MGs concentration of 1 mg/mL and 0.1 mg/mL for glucose concentrations of 16 mM and 1.6 mM at 20 °C (c).