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The effects of different ratios of two co-transfected vectors on homo-/heterodimer proportions
| Combination | Variants |
Relative yield (%) |
|||
|---|---|---|---|---|---|
| scFv-Fc | Fc | scFv-Fc/scFv-Fc homodimer | scFv-Fc/Fc heterodimer | Fc/Fc homodimer | |
| c1 | None | K392D/K409D/D399K | |||
| Ratio | 4 | 1 | 71.0 | 3.8 | 25.2 |
| 1 | 1 | 44.1 | 4.3 | 51.6 | |
| 1 | 4 | 23.8 | 4.1 | 72.1 | |
