Figure 1.

CPEB2A and CPEB2B regulate EMT/hypoxia pathways in opposing ways. A, exon structure of the CPEB2 gene. B—D, MDA-MB-231 (anoikis resistant) cells were treated with siRNA targeted toward either CPEB2A or CPEB2B. Cells were then subjected to immunoblot analysis (B) with the indicated antibodies as probes or subjected to next generation sequencing. C and D, heat maps based on the differentially regulated overlapping hypoxia/EMT and motility pathways identified by Ingenuity Pathway Analysis.