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Cumulative biliary excretions of CPT-11 (A), SN-38 (B), and SN-38G (C) following the i.v. administration of CPT-11. Biliary excretions of CPT-11 (D), SN-38 (E), and SN-38G (F) over 8 h expressed as percentages of the CPT-11 dose. The data are presented as the mean ± SEM (n = 6). *p < 0.05, **p < 0.01, significantly different from the control.
