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Effect of SXD on the concentrations of CPT-11 (A), SN-38 (B), and SN-38G (C) in the intestinal contents after the i.v. administration of CPT-11 in rats at 20 mg/kg. Each bar represents the mean ± SEM from six different rats. *p < 0.05, **p < 0.01, statistically significant difference between the control and SXD-pre-treated rats.
