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Effect of SXD on the tissue concentrations of CPT-11 (A,D), SN-38 (B,E), and SN-38G (C,F) at 8 h (A–C) and 24 h (D–F) after the i.v. administration of CPT-11 at 20 mg/kg. The data are the mean ± SEM of six independent determinations. *p < 0.05, **p < 0.01 vs. control.
