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The hydrolysis of CPT-11 (A) and glucuronidation of SN-38 (B) in both the hepatic and jejunal S9 fractions. The hydrolysis and glucuronidation rates were calculated in pmol/h/mg protein. The data are shown as the mean ± SEM of at least three independent determinations and were analyzed by Student's t-test. The asterisk (*) indicates a significant difference compared with the control, *p < 0.05, **p < 0.01.
