Table 2.

Pharmacokinetic parameters of CPT-11, SN-38, and SN-38G in control and SXD-treated rats after intravenous administration of CPT-11 at 20 mg/kg (n = 6, Mean ± SEM).

Analytes	Pharmacokinetic parameters	Groups
		SXD-treated	Control
CPT-11	AUC0 → 24h (h*ng/mL)	10022.75 ± 1049.02*	7016.64 ± 661.96
	AUC0 → ∞ (h*ng/mL)	10070.14 ± 1056.34*	7100.89 ± 682.87
	C0 (ng/mL)	4690.05 ± 306.47***	2587.52 ± 148.94
	MRT (h)	1.90 ± 0.16	2.23 ± 0.16
	CLobs (mL/h/kg)	2117.13 ± 258.05*	2947.11 ± 273.08
	Vd (mL/kg)	5747.81 ± 1051.19	10134.97 ± 1980.99
	t(1/2) (h)	1.94 ± 0.37	2.42 ± 0.45
SN-38	AUC0 → 24h (h*ng/mL)	963.02 ± 60.52**	1605.39 ± 165.09
	AUC0 → ∞ (h*ng/mL)	979.67 ± 67.41**	1642.37 ± 175.95
	Cmax (ng/mL)	179.50 ± 34.31***	325.33 ± 26.45
	MRT (h)	4.77 ± 0.32	4.93 ± 0.23
	t(1/2) (h)	3.89 ± 0.34	4.33 ± 0.29
	AUC ratio SN-38/CPT-11 (%)	10.18 ± 1.50***	22.84 ± 2.02
SN-38G	AUC0 → 24h (h*ng/mL)	518.80 ± 38.19	420.89 ± 57.47
	AUC0 → ∞ (h*ng/mL)	590.43 ± 39.43	495.02 ± 89.53
	Cmax (ng/mL)	117.53 ± 9.88**	63.03 ± 8.19
	MRT (h)	6.98 ± 0.43	7.51 ± 0.45
	t(1/2) (h)	8.17 ± 2.36	7.66 ± 1.43
	AUC ratio SN-38G/SN-38 (%)	54.62 ± 4.29**	27.69 ± 4.98

Statistical difference between control and SXD-treated rats,

^*p < 0.05,

^**p < 0.01,

^***p < 0.001.