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. 2017 Oct 31;7:14404. doi: 10.1038/s41598-017-13735-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Peptide biodistribution. (A) White light image shows individual organs from tumor-bearing mouse euthanized 1 hour after injection of KSP*-IR800, including human breast cancer xenografts (tumors), liver, heart, stomach, brain, lung, spleen, kidney, small intestine, cecum, and colon. (B) Fluorescence image shows high peptide uptake in tumors by comparison with other organs. Strong signal from kidneys support renal clearance. (C) Quantified fluorescence intensities are shown for tumor and other organs from n = 5 mice. We fit a two-way ANOVA model to log-transformed data with terms for 11 tissues and 5 mice and tested each tissue mean against the mean for tumors. Kidney had 1.7 times more intense signals on average (P = 0.03), while all other tissues had at least 2-fold lower signals than tumor on average (P = 0.008 for lung was the largest P-value).