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. 2017 Sep 29;11(11):1595–1615. doi: 10.1002/1878-0261.12134

Table 1.

Statistical evaluation of N‐ and O‐glycans implicated in the distinction of serous cancers based on their diagnosis and their tissue sampling site. The table depicts the statistically significant different glycan masses and corresponding glycan structures analysed by LC‐MS/MS in tissue samples from OC and PC patients. The columns summarize statistical evaluation results (P‐value, selected glycan by GLM and/or RF and corresponding diagnostic performance) for two comparisons, ‘diagnosis’ (OC vs. PC) and ‘tissue sampling site’ (ovary vs. peritoneum vs. omentum)

Type Glycan mass [M‐H]− [M‐2H]2− Structures OC vs. PC (diagnosis) AUC Sensitivity/specificity Ovary vs. peritoneum vs. omentum (tissue sampling site)
Level of significance Feature selection Level of significance Feature selection
P P (adj) GLM RF P P (adj) GLM RF
N‐Glycans 2411.0 1205.0 graphic file with name MOL2-11-1595-g007.jpg 0.001 0.0041 ✓ 0.93 86.7/100 0.001 0.0057
0.95+ 86.7/100+
0.97GLM 93.3/100GLM
1875.6 937.3 graphic file with name MOL2-11-1595-g008.jpg 0.001 0.0107 ✓ ✓ 0.89 86.7/92.3 0.01 0.0575 ✓ ✓
0.95+ 86.7/100+
0.97GLM 93.3/100GLM
0.93RF 86.7/100RF
2119.8 1059.4 graphic file with name MOL2-11-1595-g009.jpg 0.01 0.0777 0.001 0.0162 ✓ ✓
1713.6 856.3 graphic file with name MOL2-11-1595-g010.jpg 0.05 0.1086 ✓ ✓ 0.97GLM 93.3/100GLM
0.93RF 86.7/100RF
1990.8 994.9 graphic file with name MOL2-11-1595-g011.jpg 0.05 0.1808 ✓ 0.97GLM 93.3/100GLM 0.05 0.1555 ✓ ✓
1479.6 739.3 graphic file with name MOL2-11-1595-g012.jpg 0.05 0.2147 ✓ 0.93RF 86.7/100RF n.s. n.s. ✓
2078.8 1038.9 graphic file with name MOL2-11-1595-g013.jpg 0.05 0.2159 0.05 0.1895 ✓
2573.0 1286.0 graphic file with name MOL2-11-1595-g014.jpg 0.05 0.2850
2160.8 1079.9 graphic file with name MOL2-11-1595-g015.jpg 0.05 0.3737 ✓ 0.93RF 86.7/100RF 0.05 0.1292
2589.0 1294.0 graphic file with name MOL2-11-1595-g016.jpg 0.001 0.0162 ✓
2298.0 1148.5 graphic file with name MOL2-11-1595-g017.jpg 0.01 0.0283 ✓
1828.8 913.9 graphic file with name MOL2-11-1595-g018.jpg 0.05 0.1243 ✓
1891.6 945.3 graphic file with name MOL2-11-1595-g019.jpg 0.05 0.1880
2444.0 1221.5 graphic file with name MOL2-11-1595-g020.jpg 0.05 0.1292 ✓
2881.0 1440.0 graphic file with name MOL2-11-1595-g021.jpg 0.05 0.1785
3101.2 1550.1 graphic file with name MOL2-11-1595-g022.jpg 0.05 0.1219 ✓
O‐Glycans 749.3 – graphic file with name MOL2-11-1595-g023.jpg 0.05 0.1219 ✓
755.3 – graphic file with name MOL2-11-1595-g024.jpg n.s. n.s. ✓
1040.5 – graphic file with name MOL2-11-1595-g025.jpg 0.05 0.1880
1331.5 – graphic file with name MOL2-11-1595-g026.jpg 0.05 0.1292 ✓

+Combination AUC of top two glycan candidates; GLMCombination AUC of top four glycan candidates selected by GLM; RFCombination AUC of top four glycan candidates selected by RF. Legend: Inline graphic, Mannose (Man); Inline graphic, Fucose (Fuc); Inline graphic, Galactose (Gal); Inline graphic, N‐acetylneuraminic acid (Neu5Ac); Inline graphic, N‐acetylglucosamine (GlcNAc); Inline graphic, N‐acetylgalactosamine (GalNAc); S, Sulphate; Monosaccharide linkage: Inline graphic.