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. 2017 Oct 11;7(10):127. doi: 10.3390/brainsci7100127

Table 1.

Results of included studies.

Study Sample Methods Criteria for Diagnosis Measure Results
Mc Ausland et al. (2017) [5] n = 765 CHR Multicentric experimental study Clinical High Risk SIPS-SOPS Attenuated Psychotic Symptom scores were correlated with higher SIAS (rS = 0.12, p < 0.01) and SAS scores (rS = 0.18, p < 0.001)
280 Controls
Range age: 12–35 SAS
Severe negative symptoms were associated with higher SIAS (rS = 0.33, p < 0.001) and SAS score (rS = 0.18, p < 0.001)
IQ > 70 SIAS
Rietdijk et al. (2011) [6] n = 201 Experimental Clinical High Risk PQ Social Anxiety (SIAS > 36):42% CHR
CAARMS
Mean age: 22.7 BDI-II Gender and Social Anxiety:
Personal Assessment and Crisis Evaluation (PACE) criteria 35.4% male vs. 49% female (p = 0.05)
SD = 5.52
CDS In female patients anxiety predicted Positive Symptom Score (p = 0.038)
SIAS
Demographic questionnaire
Wigman et al. (2012) [12] n = 3021 (T0) Longitudinal study Disorders of Anxiety/Depression (DIA-X/M-CIDI) 27% of individuals with disorders of anxiety/depression reported psychotic symptoms at any time point (36% at T2; 19% at T3) vs. 14% in those without (p < 0.001).
SCL-90R
M-CIDI:
n = 2548 (T2) -Caseness:
-Help seeking Behaviour;
n = 2210 (T3) -Substance Use;
-Trauma;
Range age: 14–24 -Recent Life Events;
-Urbanicity
-Familial History of Help Seeking
Madsen et al. (2017) [13] n = 42 Experimental study Children High Risk CAARMS SCID-I Social and Occupational Functioning Assessment Scale (SOFAS): Mean 43.1 (SD6.4), (p = 0.87).
Range age: 18–40 SCID-II
Mean age = 23.8 SOFAS GF: Role: Mean 4.6 (SD 1.12), (p = 0.97).
SD = 4.7 YMRS
YMRS BPRS GF: Social: Mean 43.1 (SD 5.8), (p = 0.045).
SANS
MADRS
ASSIST CHR presented major depressive disorders (79%), anxiety (74%), alcohol (31%) and cannabis (24%).
GF: Role
GF: Social
Chudleigh et al. (2011) [14] 20 FEP Experimental study CHR CAARMS FEP and CHR participants significantly different from control on quantitative (p = 0.000) and qualitative (p < 0.001) social functioning (SFS).
20 CHR BPRS
20 controls
SFS
FEP SOFAS Only in the FEP group (p < 0.01), social anxiety symptoms were associated with both qualitative and quantitative social functioning outcomes
Range Age: 16–30 WHODAS
DASS

Abbreviations and Explanations: PQ: Prodromal Questionnaire; CAARMS: Comprehensive Assessment of At Risk Mental State; BDI-II: Beck Depression Inventory-II; CDS: Calgary Depression Scale; SIAS: Social Interaction Anxiety Scale; RCT: Randomized Clinical Trial; SCL-90R: Symptom Checklist-90-R ;DIA-X/M-CIDI: Munich-Composite International Diagnostic Interview; SOFAS: Social and Occupational Functioning Assessment Scale; SCID I: Structured Clinical Interview for DSM-IV Axis I disorders; SCID II: Structured Clinical Interview for DSM-IV Axis II disorders; SANS: Scale for the Assessment of Negative Symptoms; MADRS: Montgomery-Asberg Depression Rating Scale; SIPS-SOPS: Structured Interview for Prodromal Syndromes and the Scale for Assessment of Prodromal Symptoms; YMRS: Young Mania Rating Scale; BPRS-E Brief Psychiatric Rating Scale-Expanded version; ASSIST: Alcohol, Smoking and Substance Involvement Screening Test; GF:Role: Global Functioning: Role Scale; GF: Social: Global Functioning: Social Scale; FHI: Family History Index; SAS: Zung Self Rating Anxiety Scale; SFS: Social Functioning Scale; WHODAS: World Health Organization Disability Assessment Scale II; DASS: Depression Anxiety Stress Scale.