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Tail suspension test. The immobility time by male (A) and female (B) CD38+/+ (WT) or CD38−/− mice at 30 min after single i.p. injections of PBS, OT, LOT-1, LOT-2, or LOT-3. One-way ANOVA followed by Bonferroni’s post hoc test showed significance in the males (F6,54 = 5.922, p = 0.0001) and females (F6,38 = 7.504, p = 0.0001). * p < 0.05, ** p < 0.01, compared with CD38−/− mice treated with PBS.
