Skip to main content
. 2017 Oct 24;9(10):143. doi: 10.3390/cancers9100143

Figure 2.

Figure 2

miRNAs involved in the regulation of colorectal CSCs. (A) Schematic illustration of the miRNAs that regulates colorectal CSC functions and their targets. miR-34a, miR-200b/c, miR-203 and miR-137 are downregulated in colorectal CSCs and suppress the stem cell properties of CSCs. Among them, the expression of miR-200bc and miR-203 is coordinately regulated, and these miRNAs coordinately function for the suppression of the stem cell properties of CSCs. In contrast, miR-221 is highly expressed in CSCs and enhances the stem cell properties of CSCs. These miRNAs target genes involved in the regulation of CSC properties. RNA-binding proteins shown in red font are described in detail in Chapter 4; (B) Differential expression of miRNAs between colorectal CSCs and normal intestinal stem cells. miR-221 and miR-137 are more highly expressed in colorectal CSCs and in normal intestinal stem cells than their counterpart, respectively.