Figure 3.

Domain structures of the RBPs. Schematics illustration of the three RBPs, LIN28A/B, MSI1/2, and QKI-5/6/7/7b. LIN28A/B have two types of the RNA-binding domains, a cold shock domain (CSD) and Cys-Cys-His-Cys (CCHC) zinc finger domains. MSI1/2 have two RNA recognition motif (RRM) domains. QKI-5/6/7/7b have an RNA binding domain, KH domain which is flanked by QUA1 and QUA2 regions. The structure of QKI proteins differ at their C-terminal. NLS, a nuclear localization signal; NoLS, a nucleolar localization signal.