Figure 6.

Effect of metformin either alone or in combination with HCE on the histological architecture of the liver and pancreas, and the abundance of pancreatic islets in OLETF rats. At the termination of the experimental period, the liver (A) and pancreas (B) were excised rapidly following which tissue sections were prepared and stained with hematoxylin. The histological examination of the tissue sections was performed under a light microscope (200× magnification). Number of pancreatic islets and average area/islet are shown (C). Data with different letters are significantly different (p < 0.05) according to one way ANOVA analysis.