Table 4.
Inferred co-regeneration genes for paired tissues.
| Pair of Tissues | Ensembl ID | Gene Symbol | Full Gene Name | Betweenness | Permutation FDR | Betweenness Ratio | Min-Max Interaction Score | Major Biological Functions |
|---|---|---|---|---|---|---|---|---|
| Bone and dentine | ENSP00000231572 | RARS | Arginyl-TRNA Synthetase | 122 | <0.001 | 0.037 | 865 | Catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1. |
| ENSP00000230882 | GHR | Growth Hormone Receptor | 122 | 0.011 | 0.037 | 675 | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth, contributing to JAK2/STAT5 pathway. | |
| ENSP00000313809 | AMBN | Ameloblastin | 122 | 0.012 | 0.037 | 583 | Involves in the mineralization and structural organization of enamel. | |
| ENSP00000332353 | PTCH1 | Patched 1 | 155 | 0.033 | 0.047 | 878 | Acts as a receptor for multiple hedgehog signaling pathways. Associates with the smoothened protein (SMO) to transduce the hedgehog proteins signal. | |
| Bone and nerves | ENSP00000317272 | MET | MET Proto-Oncogene, Receptor Tyrosine Kinase/hepatocyte growth factor receptor | 802 | 0.019 | 0.023 | 989 | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor, regulating proliferation, scattering, morphogenesis and survival. |
| ENSP00000419692 | RXRA | Retinoid X Receptor Alpha | 459 | 0.026 | 0.013 | 964 | Receptor for retinoic acid. Binds as heterodimers to its target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulates gene expression in various biological processes. | |
| ENSP00000228682 | GLI1 | GLI Family Zinc Finger 1 | 407 | 0.044 | 0.012 | 978 | Regulates the transcription of specific genes during normal development. Plays a role in development of multiple tissues. Mediates SHH signaling. | |
| Bone and vessels | ENSP00000295731 | IHH | Indian Hedgehog | 486 | 0.014 | 0.015 | 912 | Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. |
| ENSP00000317272 | MET | MET Proto-Oncogene, Receptor Tyrosine Kinase/hepatocyte growth factor receptor | 634 | 0.018 | 0.02 | 984 | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor, regulating proliferation, scattering, morphogenesis and survival. | |
| ENSP00000371067 | JAK2 | Janus Kinase 2 | 853 | 0.021 | 0.027 | 994 | Non-receptor tyrosine kinase involving in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. | |
| ENSP00000419692 | RXRA | Retinoid X Receptor Alpha | 353 | 0.026 | 0.011 | 964 | Receptor for retinoic acid. Binds as heterodimers to its target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulates gene expression in various biological processes. | |
| Dentin and nerves | ENSP00000360483 | NDC1 | NDC1 Transmembrane Nucleoporin | 280 | 0.004 | 0.037 | 466 | Component of the nuclear pore complex (NPC), contributing to de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly. |
| ENSP00000313809 | AMBN | Ameloblastin | 280 | 0.012 | 0.037 | 819 | Involves in the mineralization and structural organization of enamel. | |
| ENSP00000231572 | RARS | Arginyl-TRNA Synthetase | 281 | 0.015 | 0.037 | 865 | Catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1. | |
| ENSP00000230882 | GHR | Growth Hormone Receptor | 281 | 0.04 | 0.037 | 675 | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth, contributing to J AK2/STAT5 pathway. | |
| Dentin and vessels | ENSP00000231572 | RARS | Arginyl-TRNA Synthetase | 258 | 0.003 | 0.037 | 865 | Catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1. |
| ENSP00000362649 | HDAC1 | Histone Deacetylase 1 | 112 | 0.01 | 0.016 | 993 | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones. Gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | |
| ENSP00000262077 | NUP153 | Nucleoporin 153 | 251 | 0.024 | 0.036 | 456 | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. | |
| ENSP00000387662 | GCG | Glucagon | 76 | 0.026 | 0.011 | 896 | Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose. Raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. | |
| ENSP00000227507 | CCND1 | Cyclin D1 | 263 | 0.03 | 0.038 | 946 | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. | |
| ENSP00000332973 | SMAD3 | SMAD Family Member 3 | 490 | 0.038 | 0.07 | 875 | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-β (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-β and, on formation of the SMAD3/SMAD4 complex, activates transcription. | |
| ENSP00000332353 | PTCH1 | Patched 1 | 131 | 0.044 | 0.019 | 878 | Acts as a receptor for multiple hedgehog signaling pathways. Associates with the smoothened protein (SMO) to transduce the hedgehog proteins signal. | |
| ENSP00000250003 | MYOD1 | Myogenic Differentiation 1 | 208 | 0.048 | 0.0299 | 848 | Promotes transcription of muscle-specific target genes in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. | |
| Nerves and vessels | ENSP00000250003 | MYOD1 | Myogenic Differentiation 1 | 2465 | 0.005 | 0.034 | 999 | Promotes transcription of muscle-specific target genes in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. |
| ENSP00000340944 | PTPN11 | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | 1350 | 0.01 | 0.019 | 999 | Involved in intracellular signal transduction in response to PDGF, EGF, insulin. | |
| ENSP00000227507 | CCND1 | Cyclin D1 | 3568 | 0.022 | 0.049 | 991 | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. | |
| ENSP00000371067 | JAK2 | Janus Kinase 2 | 2332 | 0.031 | 0.032 | 999 | Non-receptor tyrosine kinase involving in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. |