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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: JAMA Dermatol. 2015 Jun;151(6):627–634. doi: 10.1001/jamadermatol.2014.5641

Figure 3. Expression of Surface Activation Markers in Different Temperature Settings.

Figure 3

A and B, Mean surface CD11b expression (mean fluorescence intensity [MFI]) in neutrophils (A) and monocytes (B) among healthy controls and patients with PLCG2-associated antibody deficiency and immune dysregulation (PLAID) at ambient temperatures. Error bars indicate SD. C and D, Mean surface CD11b expression (MFI) in neutrophils (C) and monocytes (D) among healthy controls and patients with PLAID at warm temperatures. Error bars indicate SD. E and F, Median relative expression of CD11b in ambient compared with warm temperatures in neutrophils (E) and monocytes (F) from patients with PLAID and healthy controls. Relative MFI of CD11b is calculated as (MFIambient/MFIwarm). Error bars indicate interquartile range. G, Basal superoxide production in neutrophils from patients with PLAID compared with healthy controls at 20°C, 30°C, and 37°C. H, Neutrophil superoxide production in response to tumor necrosis factor α in patients with PLAID.

aP < .05 (unpaired t test and Wilcoxon signed rank test).

bP < .01 (unpaired t test and Wilcoxon signed rank test).

cP < .001 (unpaired t test and Wilcoxon signed rank test).

dP < .33 (unpaired t test and Wilcoxon signed rank test).

eP = .78 (unpaired t test and Wilcoxon signed rank test).