Table 2.
Comparison of Patients Receiving Vancomycin and Patients Who Did Not Receive Vancomycin.
| Overall Results (N = 162) | Topically Applied Vancomycin (n = 81) | No Vancomycin (n = 81) | P Value | |
|---|---|---|---|---|
| Age, mean (SD), y | 60.1 (10.8) | 60.6 (10.9) | 59.5 (10.8) | <.05 |
| Gender, % males (n) | 59.3 (96) | 59.3 (48) | 59.3 (48) | .1193 |
| BMI, mean (SD) | 34.8 (7.7) | 34.5 (7.2) | 35.1 (8.2) | .5859 |
| Duration of DM, median (25%, 75% interquartile range), y | 10.0 (5.0, 20.0) | 10.0 (5.0, 19.0) | 10.0 (4.0, 24.0) | .3602 |
| Type of DM, % type 2 (n) | 87.7 (142) | 93.8 (76) | 81.5 (66) | <.0001 |
| Insulin use, % (n) | 49.4 (80) | 49.4 (40) | 49.4 (40) | 1.000 |
| Serum glucose mg/dl, median (25%, 75% interquartile range) | 131.5 (105.0, 160.0) | 131.0 (106.0, 171.0) | 132.0 (103.0, 156.0) | .3363 |
| Hemoglobin A1c%, median (25%, 75% interquartile range) | 7.0 (6.3, 8.2) | 7.0 (6.4, 8.2) | 8.0 (6.2, 8.1) | .5906 |
| Serum creatinine mg/dl, median (25%, 75% interquartile range) | 1.0 (0.8, 1.2) | 0.9 (0.8, 1.2) | 1.1 (0.9, 1.3) | <0.01 |
| Hemoglobin gr/dl, mean (SD) | 12.9 (1.8) | 13.0 (1.8) | 12.8 (1.6) | .2459 |
| ASA classification, % (n) | .5629 | |||
| 2 | 9.9 (16) | 8.6 (7) | 11.1 (9) | |
| 3 | 84.0 (136) | 87.7 (71) | 80.3 (65) | |
| 4 | 6.2 (10) | 3.7 (3) | 8.6 (7) | |
| Presence or absence of ulcer, % (n) | 22.8 (37) | 25.9 (21) | 19.8 (16) | <.0001 |
| Active or former smoker, % (n) | 29.6 (48) | 33.3 (27) | 25.9 (21) | <.001 |
| Active smoker current, % (n) | 17.9 (29) | 17.3 (14) | 18.5 (15) | <.0001 |
| Presence of Charcot neuropathy, % (n) | 36.4 (59) | 38.3 (31) | 34.6 (28) | <.05 |
| Peripheral artery disease, % (n) | 15.4 (25) | 11.1 (9) | 19.8 (16) | <.0001 |
| Neuropathy, % (n) | 77.8 (126) | 75.3 (61) | 80.3 (65) | <.001 |
| Michigan Neuropathy Screening Index, median (25%, 75% interquartile range) | 6.0 (3.0, 7.0) | 6.0 (2.0, 8.0) | 5.5 (3.0, 7.0) | .8307 |
| Follow-up duration, median (25%, 75% interquartile range), wk | 52.0 (26.0, 100.0) | 44.0 (24.0, 78.0) | 60.0 (27.0, 104.0) | <.05 |
| Length of surgery, mean (SD), min | 147.5 (64.3) | 147.8 (66.6) | 147.2 (62.3) | .9137 |
| No. of procedures performed during surgery, median (25%, 75% interquartile range) | 3.0 (2.0, 4.0) | 3.0 (2.0, 4.0) | 3.0 (2.0, 3.0) | <.01 |
| Overall infection, % (n) | 11.7 (19) | 4.9 (4) | 18.5 (15) | <.05 (OR, 0.267; 95% CI, 0.089–0.803) |
| Superficial infection, % (n) | 4.3 (7) | 2.5 (2) | 6.2 (5) | .2734 (OR, 0.400; 95% CI, 0.078–2.062) |
| Deep infection, % (n) | 7.4 (12) | 2.5 (2) | 12.4 (10) | <.05 (OR, 0.200; 95% CI, 0.044–0.913) |
Abbreviations: ASA, American Society of Anesthesiologists; BMI, body mass index; DM, diabetes mellitus; OR, odds ratio.