Table 2.
Co-morbid conditions and immunosuppressive medications present within 30 days before the diagnosis of an endemic fungal infection in hematopoietic cell and solid organ transplant recipients
| Number (%)
|
|||
|---|---|---|---|
| Co-morbid condition/drug
|
Blastomycosis (N = 9)
|
Coccidioidomycosis (N = 9)
|
Histoplasmosis (N = 52)
|
| Diabetes mellitus | 6 (67) | 0 | 14 (27) |
| Malnutrition | 5 (56) | 0 | 3 (6) |
| Chronic lung disease | 3 (33) | 0 | 3 (6) |
| Congestive heart failure | 2 (22) | 0 | 2 (4) |
| Chronic kidney disease | 3 (33) | 3 (33) | 19 (37) |
| Hepatic insufficiency | 1 (11) | 0 | 7 (13) |
| Rheumatologic disease | 0 | 0 | 2 (4) |
| Rejection episode1 | 1 (11) | 1 (11) | 3 (6) |
| Immunosuppressive drugs | |||
| Corticosteroids2 | 9 (100) | 8 (89) | 45 (87) |
| Calcineurin inhibitors | 8 (89) | 7 (78) | 39 (75) |
| Mycophenolate | 6 (67) | 7 (78) | 27 (52) |
| Sirolimus | 0 | 0 | 5 (10) |
| Azathioprine | 0 | 0 | 1 (2) |
1
Within 6 weeks of the diagnosis of an endemic mycosis.
2
Equivalent of ≥20 mg prednisone daily (methylprednisolone, dexamethasone, prednisone).