Table 6.
Treatment of endemic mycoses in hematopoietic cell and solid organ transplant recipients
| Number (%)
|
|||
|---|---|---|---|
| Antifungal agent
|
Blastomycosis (N = 9)
|
Coccidioidomycosis (N = 9)
|
Histoplasmosis (N = 52)
|
| AmB, then Itra | 2 (22) | 0 | 26 (50) |
| AmB, then Vori | 1 (11) | 0 | 0 |
| AmB + azole1 | 2 (22) | 0 | 1 (2) |
| AmB | 0 | 2 (22) | 5 (10) |
| Itra | 0 | 0 | 10 (19) |
| Vori | 3 (33) | 1 (11) | 1 (2) |
| Flu | 0 | 2 (22) | 1 (2) |
| Azoles2 | 1 (11) | 1 (11) | 4 (8) |
| Azole, then AmB3 | 0 | 1 (11) | 3 (6) |
| None4 | 0 | 2 (22) | 1 (2) |
1
Blastomycosis: AmB + vori (in 2); Histoplasmosis: AmB + Flu (in 1).
2
Blastomycosis: Vori, then Itra (in 1); Coccidioidomycosis: Vori, then Itra (in 1); Histoplasmosis: Vori, then Flu (in 1), Vori, then Itra (in 1), Itra then Flu then Vori (in 1), Itra then Vori then Posa (in 1).
3
Coccidioidomycosis: Flu then Vori then AmB (in 1); Histoplasmosis: Itra then AmB (in 3).
4
Diagnosis made after death.
AmB, amphotericin B; Itra, itraconazole; Flu, fluconazole; Vori, voriconazole; Posa, posaconazole.