. Author manuscript; available in PMC: 2018 Oct 31.

Published in final edited form as: Dalton Trans. 2017 Oct 31;46(42):14591–14601. doi: 10.1039/c7dt01819c

Table 3.

Dose Escalation of i.p. Injected ²²⁷Th-mAb: Median Survival of Athymic Mice Bearing i.p. LS-174T Tumor Xenografts

Dose (μCi)	None	²²⁷Th-Trastuzumab		²²⁷Th-Panitumumab		²²⁷Th-HUM195
Dose (μCi)	None	Median Survival (d)	Therapeutic Index	Median Survival (d)	Therapeutic Index	Median Survival (d)	Therapeutic Index
0	14
0.25		17	1.2	21	1.5	14	1.0
0.5		30	2.1	30	2.1	14	1.0
1.0		30	2.1	24	1.7	11	0.8
2.0		18	1.3	14	1.0	14	1.0
5.0		14	1.0	11	0.8	14	1.0

Therapuetic Index is the median survival of the treatment group divided by the median survival of the untreated group.