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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Sep 4;234(22):3361–3373. doi: 10.1007/s00213-017-4726-2

Figure 3.

Figure 3

Effects of treatment drugs on choice between immediate remifentanil ("remi") and delayed food (food-remi choice), on self-administration of remifentanil when the alternative response produced only timeout (remi only), and on self-administration of delayed food when the alternative response produced only timeout (food only). a: Percent choice of the food hole as a function of lorcaserin dose in the food-remi choice schedule. b: Intake of food and remifentanil (choices per session) as a function of lorcaserin dose in the food-remi schedule. (Details of within-curve differences: For the drug hole, 1.7 differs from vehicle and 3, and 3 differs from all other doses.) c: Percent choice of the food hole as a function of naltrexone dose in the food-remi choice schedule. (Details of within-curve difference: 30 differs from vehicle.) d: Intake of food and remifentanil as a function of naltrexone dose in the food-remi choice schedule. (Details of within-curve differences: For the drug hole, all doses differ from vehicle.) e: Percent choice of the food hole as a function of lorcaserin dose in the remi-only schedule. f: Number of choices of the food and remifentanil holes as a function of lorcaserin dose in the remi-only schedule. (Details of within-curve differences: For the drug hole, 3 differs from vehicle.) g: Percent choice of the food hole as a function of naltrexone dose in the remi-only schedule. h: Number of choices of the food and remifentanil holes as a function of naltrexone dose in the remi-only schedule. (Details of within-curve differences: For the drug hole, all points differ from vehicle.) i: Percent choice of the food hole as a function of lorcaserin dose in the food-only schedule. j: Number of choices of the food and remifentanil holes as a function of lorcaserin dose in the food-only schedule. (Details of within-curve differences: For the food hole, 1.7 and 3 differ from vehicle and 0.3. For the drug hole, 3 differs from vehicle.) k: Percent choice of the food hole as a function of naltrexone dose in the food-only schedule. l: Number of choices of the food and remifentanil holes as a function of naltrexone dose in the food-only schedule. * differs within curve. # differs between food and drug holes at the same dose.