Scheme 2. Cyclization of 3 in 7 : 3 DMSO/H2O with 0.1 M oxalic acid at 60 °C after (a) 0 h (b) 2 h. (c) Purified depsi-4. (d) O,N-Acyl shift of depsi-4 at pH 11 in 2 : 1 CH3CN/H2O (200 mM phosphate buffer) after 4 h and (e) after 18 h.
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