Table 2. Results of the cyclic peptide library synthesis by protected cyclization in solution (method A) and by KAHA cyclization (method B).

^aHighlighted residues indicate the distinctive position of similar sequences with and without a turn inducing template. The last position indicates the α-ketoacid used for cyclization (Leu or Phe). The peptide concentration for cyclization was 6.25 mM for both methods. [T^§ = (S)-homoserine].

^bIsolated yields on 50 μmol scale after RP-HPLC purification.

^cDetermined by HPLC as relative area% at 220 nm.

^dGypsophin B²⁵ analogue.

^ePseudostellarin G²⁵ analogue.

^fSegetalin F²⁵ analogue.