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. 2017 Aug 31;102(11):1878–1889. doi: 10.3324/haematol.2017.173419

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Figure 6. — IT-901 co-operates with ibrutinib in inducing apoptosis of chronic lymphocytic leukemia (CLL) cells. Cumulative results of apoptosis of primary CLL cells (n=16) cultured alone (A) or over autologous nurse-like cells (NLC) (B) for 48 hours (h) in the presence of ibrutinib (2.5 μM) and IT-901 (5 and 10 μM) alone or in combination. Statistical significance of the combined effect of IT-901 and ibrutinib compared to single drugs alone was calculated according to the effect-based strategy, using the Highest Single Agent approach, as described by Foucquier and Guedj.³⁴ *Over single box plot indicates statistical significance compared to untreated (NT).