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. 2017 Aug 24;102(11):1890–1900. doi: 10.3324/haematol.2017.170571

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Figure 3. — B-cell activating factor (BAFF) activates BCR signaling in chronic lymphocytic leukemia (CLL) cells. (A–C) CLL cells were stimulated with 5 μg/μL sol-IgM or 25 ng/μL sol-BAFF. Cells were lysed at the indicated time points and subjected to immunoblotting. A representative result of 10 independent experiments is shown (includes 4 unmut-IGHV and 6 mut-IGHV). Densitometry (C) was performed on immunoblots from 10 individual CLL samples after 15 minutes (min) stimulation with IgM or BAFF. (D) CLL cells were incubated or not with idelalisib (5 μM) for 1 hour (h) and stimulated with sol-IgM or sol-BAFF for 30 min. Cell migration using 200 ng/mL CXCL12 was evaluated as described in the Methods section. P<0.05 versus control.